Okay, update.
Lets see here. After another great war against the Ottomans, I brutalized them so much they couldn't repel the following waves of rebellions, and so a whole group of nations have regained independence, including the long lost Byzantine empire. The Ottomans are now standing on their last legs.
Castille has lost all European land and most of their South American colonies, but their scattered and distant colonies makes them damn hard to get rid of. Austria is becoming a damn pain in the ass, constantly making spy attacks on me as well as trying to get me excommunicated by the church (again).
Wales got cocky, so I had to take half their country.
Oh, and the Mayans are now the Papal controller somehow.