First off, I would first like to point out that all three possible endings sucks. With this, it's like Bioware are making sculptures out of porridge - the best you do is still excrement and everyone around wonders what the gently-carress you're doing. The moment I realized that it wouldn't matter which ending I chose - it would go to excrement for Shepard anyway - was like a punch in the gut from BW.
Now, I chose to destroy synthetic life because I wanted to down those Reaper bastards, but it also slaughtered the Mass Effect universe and my view on it. I had hoped the game would end with the total demise of the Reapers and Shepard can cruise through the galaxy with Tali and Garrus, maybe go bowling, take a drink at Purgatory. Instead, the Citadel is gently-carressing destroyed with Shepard in it! And BW tries to make it all good by showing he survived, but it doesn't gently-carressing matter! He is still trapped under 14 million tons of rubble, and it seems every gently-carressing Mass Relay in the galaxy is destroyed!
I wanted the game universe to go back to "normal" after the Reapers, but instead the entire galactic society that made us love ME is gently-carressing gone because no one can travel across the galaxy anymore with the destruction of the relays! It didn't get very much better by seeing the Normandy Crew crashing on a seemingly inhabited jungle planet where they will live out the rest of their days, maybe driven insane by their solitude from their own peoples.
And then was the sacrifices. Mordin, Legion, everyone who died in the war against the Reapers. We never got to see the galaxy reaping the benefits off it, just told that it would be absolutely great and they expected us to accept that. I want to see how the krogan do now that they genophage is cured, dammit!
And now, here are the three things I absolutely hate the most - first, I didn't get to fight the gently-carressing bastard TIM as I had been waiting to do since I first completed ME2, because that sum'bitch had to pull a Saren!
Next, since she is now stuck on a gently-carressing jungle world, Tali could never go back to Rannoch due to lack of transport. Ever since I first met Tali in ME1 and found out she had no homeworld, I was determined to see her finally getting it. And she had it! For an hour! Now she'll probably never see it again! And I don't know, maybe the world is inhabited, but that still won't help since every gently-carressing relay is destroyed!
Ah, yes, another thing. Now that every relay is gone, the billions of people who live on colonies will now be isolated, completely cut off and some will wither and die from not being able to get to their homeworld. Those colonies who are completely self-sustained will form their own people, their own nations. I think this sucks as well, since it's just another point that the galactic society is gone.
And one of the, to me, worst things of all - the final gently-carress You from the Bioware Corporations...it was a gently-carressing story! It was all just a gently-carressing story some dude told to a little child! And the sentence "It happened so very long ago" kills just about all that was left of the Mass Effect experience. It's no longer an epic journey to save the future galaxy as a badass commander with awesome aliens at my side - it's a story. A mothergently-carressing bedtime story for a kid!
Was this it? Was this the moment we had waited five years for? To find out that this grand journey through the galaxy, fighting mercenaries, monsters, aliens, gently-carressing galactic destroyers, was all just a story told by some elder man - who could have just blatantly made the story up? Those two were human. Does that mean that the turian, asari, krogan, hanar, quarian, salarian etc never existed and might have just been made up? Well if that's the case, then I hope BW makes that gently-carressing DLC and makes it well!
I'm gamer Tobbs, and the Destroy Synthetics-end pisses me off.